Immunohistochemical and molecular genetic analyses of multiple sporadic gastrointestinal stromal tumors
نویسندگان
چکیده
منابع مشابه
Gastrointestinal stromal tumors: clinicopathological and immunohistochemical features.
OBJECTIVES To study the clinicopathological and immunohistochemical features of gastrointestinal stromal tumors (GISTs) in Kuwait. MATERIALS AND METHODS Hematoxylin- and eosin-stained sections of primary gastrointestinal mesenchymal tumors were reviewed. Immunohistochemical staining was performed using a panel of antibodies to determine muscle and neural differentiation, the incidence of CD11...
متن کاملGenetic progression in gastrointestinal stromal tumors: mechanisms and molecular interventions
Gastrointestinal stromal tumors (GISTs) are the most common sarcomas in humans. Constitutively activating mutations in the KIT or PDGFRA receptor tyrosine kinases are the initiating oncogenic events. Most metastatic GISTs respond dramatically to therapies with KIT/PDGFRA inhibitors. Asymptomatic and mitotically-inactive KIT/PDGFRA-mutant "microGISTs" are found in one third of adults, but most o...
متن کاملHistological and Immunological Evaluation of Gastrointestinal Stromal Tumors
Background: Gastrointestinal stromal tumors (GISTs) constitute the majority of gastrointestinal mesenchymal tumors. They usually express a proto-oncogen protein called CD117 detected by immunohistochemistry. This study investigated the differentiation of GISTs as well as the risk of aggressive behaviors in GISTs from surgically-treated patients in university affiliated hospitals. Methods: The c...
متن کاملSynchronous sporadic gastrointestinal stromal tumors (GISTs) of the colon.
Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the gastrointestinal tract originating from the cell of Cajal [1]. Up to 75% of cases are driven by constitutional activation of the proto-oncogene cKIT; 10% by a mutation of the gene encoding for the platelet-derived growth factor receptor (PDGFRA); 12% are wild-type and their pathogenesis has been related to mutations of t...
متن کاملMolecular characterization of pediatric gastrointestinal stromal tumors.
PURPOSE Pediatric gastrointestinal stromal tumors (GIST) are rare and occur preferentially in females as multifocal gastric tumors, typically lacking mutations in KIT and PDGFRA. As KIT oncoprotein is consistently overexpressed in pediatric GIST, we sought to investigate the activation of KIT downstream targets and alterations of KIT/PDGFRA gene copy number, mine novel therapeutic targets by ge...
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ژورنال
عنوان ژورنال: World Journal of Gastrointestinal Oncology
سال: 2010
ISSN: 1948-5204
DOI: 10.4251/wjgo.v2.i9.364